Invited Lecture: DNA self-assembly and DNA nanotechnology

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Bottom-up self-assembly of DNA nanostructures have been proposed for variety of biotech uses ranging from information storage, to targeted drug delivery or scaffolding for new materials. Engineering predefined building blocks at nano level with various chiralities that assemble in large 3D crystallographic structures is an essential step for both 3D algorithmic assemblies as well as for spatial information storage. We will discuss some recent developments in the field and will focus on spatial systems as models for information processing at molecular level. The rationally-designed 3D DNA motif, the tensegrity triangle, is the first DNA molecule used to provide DNA crystallographic assemblies. The possibilities of these building blocks give ever-increasing geometric complexities that form vast arrays of three-dimensional structures. We show a model that explains and predicts which tensegrity triangle structures can form and which chiral topology they can form, left- or right-handed. The theoretical model is also experimentally verified through units designed with incremental rotational steps.
Speaker(s): Prof. Natasha Jonoska, PhD,
University Ss. Cyril and Methodius, Faculty of Computer Science and Engineering, Rudzer Boshkovikj 16, Skopje, Macedonia, Macedonia, 1000

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